IkB-α(N-term) Mouse mAb
Source: Mouse mAb Catalog No. : AB3178
IkB-α(N-term) Mouse mAb (AB3178)
UniProt:P25963
Application:WB
Reactivity:Human,Mouse
Source:Mouse mAbhttp://www.abways.cn/showproduct.asp?cid=AB3178
数据表
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UniProt
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Mol Weight36KDa
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Alternative NamesI-kappa-B-alpha; NFKBI; NFKBIA; Major histocompatibility complex enhancer-binding protein MAD3; NF-kappaB inhibitor alpha; IKBA; IkappaBalpha; MAD3; RL/IF-1
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ImmunogenPurified recombinant human IkB-alpha(N-terminus) protein fragments expressed in E.coli.
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StorageMouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeMouse
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ClonalityMonoclonal
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DescriptionInhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription
Applications
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ReactivityHuman,Mouse
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ApplicationWB
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Recommended dilutionWB 1:500-1000
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Western blot detection of IkB-alpha(N-terminus) in Jurkat and Hela cell lysates using IkB-alpha(N-terminus) mouse mAb (1:1000 diluted).Predicted band size: 36KDa.Observed band size: 36KDa.
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