DR5 Mouse mAb
Source: Mouse mAb Catalog No. : AB3251
DR5 Mouse mAb (AB3251)
UniProt:O14763
Application:WB,ICC/IF
Reactivity:Human,Mouse
Source:Mouse mAbhttp://www.abways.cn/showproduct.asp?cid=AB3251
数据表
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UniProt
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Mol Weight48KDa
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Alternative NamesDeath receptor 5; TRAIL receptor 2; TRAIL-R2; CD262; TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9;
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ImmunogenPurified recombinant human DR5 protein fragments expressed in E.coli.
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StorageMouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeMouse IgG1
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ClonalityMonoclonal
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DescriptionReceptor for the cytotoxic ligand TNFSF10/TRAIL.The adapter molecule FADD recruits caspase-8 to the activated receptor.The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Applications
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ReactivityHuman,Mouse
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ApplicationWB,ICC/IF
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Recommended dilutionWB 1:500-2000 ICC/IF 1:100
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Western blot detection of DR5 in Mouse kindey,Mouse brain,HCT116 and Hela cell lysates using DR5 mouse mAb (1:500-1:2000 diluted).Predicted band size:40/48KDa.Observed band size:40/48KDa. -
Immunofluorescent analysis of HeLa cells fixed by Paraformaldehyde and using DR5 mouse mAb diluted 1:100.
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