DR5 Mouse mAb_单克隆抗体-上海泊湾生物技术有限公司

DR5 Mouse mAb

Source: Mouse mAb Catalog No. : AB3253

DR5 Mouse mAb (AB3253)
UniProt:O14763
Application:WB
Reactivity:Human
Source:Mouse mAbhttp://www.abways.cn/showproduct.asp?cid=AB3253

数据表

UniProt

O14763
Mol Weight

40,48KDa
Alternative Names

Death receptor 5; TRAIL receptor 2; TRAIL-R2; CD262; TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9;
Immunogen

Purified recombinant human DR5 protein fragments expressed in E.coli.
Storage

Mouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Purification

Affinity-chromatography
Isotype

Mouse IgG2b
Clonality

Monoclonal
Description

Receptor for the cytotoxic ligand TNFSF10/TRAIL.The adapter molecule FADD recruits caspase-8 to the activated receptor.The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

Applications

Western blot detection of DR5 in SW480,K562,HCT116 and Hela cell lysates using DR5 mouse mAb (1:1000 diluted).Predicted band size:40/48KDa.Observed band size:40/48KDa.