HDAC6 (3B2) Mouse mAb
Source: Mouse mAb Catalog No. : AB3394
HDAC6 (3B2) Mouse mAb (AB3394)
UniProt:Q9UBN7
Application:WB
Reactivity:Human
Source:Mouse mAbhttp://www.abways.cn/showproduct.asp?cid=AB3394
数据表
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UniProt
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Mol Weight160kDa
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Alternative NamesHD6;JM21;CPBHM;PPP1R90;HDAC6
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ImmunogenPurified recombinant human HDAC6 protein expressed in E.coli.
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StorageMouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeMouse IgG2a
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ClonalityMonoclonal
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DescriptionSwiss-Prot Acc.Q9UBN7.Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases.
Applications
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ReactivityHuman
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ApplicationWB
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Recommended dilutionWB 1:500-1:1000
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Western blot detection of HDAC6 in T47D,Jurkat CHO-K1(B) and CHO-K1 transfected by HDAC6-fragment EGFP fusion protein cell lysates using HDAC6 mouse mAb (1:1000 diluted).
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