P35232

30kDa

PHB1; HEL-215; HEL-S-54e

Purified recombinant fragment of human PHB expressed in E. Coli.

Mouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Affinity-chromatography

Mouse IgG1

Monoclonal

Swiss-Prot Acc.P35232.Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.

Human,Mouse,Rat,Monkey

WB,IHC,ICC/IF,FC

WB: 1/500-1/1000 IHC: 1/50-1/100 ICC/IF: 1/50-1/200 FC: 1/50-1/100