KIF7 (2A7) Mouse mAb
Source: Mouse mAb Catalog No. : AB3514
KIF7 (2A7) Mouse mAb (AB3514)
UniProt:Q2M1P5
Application:IHC,ICC/IF
Reactivity:Human,Mouse,Rat
Source:Mouse mAbhttp://www.abways.cn/showproduct.asp?cid=AB3514
数据表
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UniProt
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Mol WeightkDa
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Alternative Nameskinesin like protein KIF7; EQYK340; kif7
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ImmunogenSynthetic Peptide of Kif 7
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StorageMouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeMouse IgG1
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ClonalityMonoclonal
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DescriptionSwiss-Prot Acc.Q2M1P5.Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes . Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation . Involved in the regulation of epidermal differentiation and chondrocyte development .
Applications
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ReactivityHuman,Mouse,Rat
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ApplicationIHC,ICC/IF
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Recommended dilutionIHC: 1/50-1/100 ICC/IF: 1/50-1/200
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Immunohistochemistry analysis of paraffinembedded Mouse Kidney tissue using KIF7 (2A7) antibody -
Immunofluorescence analysis of KIF7 (2A7) in Mousecolon tissue using KIF7 (2A7) antibody(red),and DAPI (blue).
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