Caspase-3 (1B10) Mouse mAb
Source: Mouse mAb Catalog No. : AB3576
Caspase-3 (1B10) Mouse mAb (AB3576)
UniProt:P42574
Application:IHC
Reactivity:Human,Mouse,Rat
Source:Mouse mAbhttp://www.abways.cn/showproduct.asp?cid=AB3576
数据表
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UniProt
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Mol Weight17,32kDa
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Alternative NamesCASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1
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ImmunogenSynthetic peptide conjugated to KLH.
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StorageMouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeMouse IgG1
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ClonalityMonoclonal
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DescriptionSwiss-Prot Acc.P42574.Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Applications
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ReactivityHuman,Mouse,Rat
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ApplicationIHC
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Recommended dilutionIHC: 1/50-1/100
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Immunohistochemistry analysis of paraffinembedded Human Skin Tissue using Caspase 3 (1B10) antibody. -
Immunohistochemical analysis of paraffinembedded human tonsils using Caspase 3 (1B10) antibody. -
Immunohistochemistry analysis of paraffinembedded Mouse Liver Tissue using Caspase3 antibody.
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