HP1 alpha (1E8) Mouse mAb
Source: Mouse mAb Catalog No. : AB3615
HP1 alpha (1E8) Mouse mAb (AB3615)
UniProt:P45973
Application:WB,IHC
Reactivity:Human,Mouse,Rat
Source:Mouse mAbhttp://www.abways.cn/showproduct.asp?cid=AB3615
数据表
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UniProt
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Mol Weight22kDa
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Alternative NamesCBX5; HP1A; Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha
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ImmunogenPurified recombinant protein expressed in E.coli.
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StorageMouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeMouse IgG1
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ClonalityMonoclonal
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DescriptionSwiss-Prot Acc.P45973.Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Applications
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ReactivityHuman,Mouse,Rat
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ApplicationWB,IHC
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Recommended dilutionWB: 1/500-1/1000 IHC: 1/50-1/100
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Western blot analysis of HP1 alpha (1E8) in COS7,Hela lysates using HP1 alpha (1E8) antibody. -
Immunohistochemistry analysis of paraffinembedded Human Colon Carcinoma Tissue using HP1 alpha (1E8) antibody. -
Immunohistochemical analysis of paraffinembedded human tonsils using HP1 alpha (1E8) antibody. -
Immunohistochemistry analysis of paraffinembedded Human Placenta Tissue using HP1 alpha (1E8) antibody.
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