Bcl-2 (9A4) Mouse mAb
Source: Mouse mAb Catalog No. : AB3629
Bcl-2 (9A4) Mouse mAb (AB3629)
UniProt:P10415
Application:WB
Reactivity:Human,Mouse,Rat
Source:Mouse mAbhttp://www.abways.cn/showproduct.asp?cid=AB3629
数据表
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UniProt
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Mol Weight26kDa
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Alternative NamesBCL2; Apoptosis regulator Bcl-2
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ImmunogenSynthetic peptide conjugated to KLH.
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StorageMouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeMouse IgG1
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ClonalityMonoclonal
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DescriptionSwiss-Prot Acc.P10415.Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
Applications
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ReactivityHuman,Mouse,Rat
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ApplicationWB
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Recommended dilutionWB: 1/500-1/1000
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Western blot analysis of BCL2 in THP1 lysates using BCL2 Mouse Monoclonal Antibody.
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