PI3 Kinase p85 alpha (1C8) Mouse mAb
Source: Mouse mAb Catalog No. : AB3637
PI3 Kinase p85 alpha (1C8) Mouse mAb (AB3637)
UniProt:P27986
Application:WB,IHC
Reactivity:Human,Mouse,Rat
Source:Mouse mAbhttp://www.abways.cn/showproduct.asp?cid=AB3637
数据表
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UniProt
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Mol Weight85kDa
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Alternative NamesPIK3R1; GRB1; PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha
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ImmunogenPurified recombinant protein expressed in E.coli.
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StorageMouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeMouse IgG1
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ClonalityMonoclonal
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DescriptionSwiss-Prot Acc.P27986.Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
Applications
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ReactivityHuman,Mouse,Rat
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ApplicationWB,IHC
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Recommended dilutionWB: 1/500-1/1000 IHC: 1/50-1/100
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Western blot analysis of PI3 Kinase p85 alpha in Jurkat,Rat Brain,Raw264.7,Ramos,Raji lysates using PI3 Kinase p85 alpha (1C8) antibody. -
Immunohistochemistry analysis of paraffinembedded Rat Liver Tissue using PI3 Kinase p85 alpha (1C8) antibody. -
Immunohistochemical analysis of paraffinembedded human tonsils using PI3 Kinase p85 alpha (1C8) antibody.
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