TR11B Antibody
Source: Rabbit pAb Catalog No. : AY0106
TR11B Antibody (AY0106)
UniProt:O00300
Application:WB
Reactivity:Human,Mouse
Source:Rabbit pAbhttp://www.abways.cn/showproduct.asp?cid=AY0106
数据表
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UniProt
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Mol Weight56 kDa
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Alternative NamesTumor necrosis factor receptor superfamily member 11B [Precursor], Osteoprotegerin, Osteoclastogenesis inhibitory factor, TNFRSF11B, OCIF, OPG
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ImmunogenThe antiserum was produced against synthesized peptide derived from Internal of human TR11B.
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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IsotypeRabbit IgG
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ClonalityPolyclonal
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DescriptionActs as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Applications
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ReactivityHuman,Mouse
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ApplicationWB
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Recommended dilutionWB: 1:500~1:3000 ELISA: 1:5000
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Western blot analysis of extracts from 293 cells, using TR11B antibody.
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