Phospho-RFA2 (Ser33) Antibody
Source: Rabbit pAb Catalog No. : AY0326
Phospho-RFA2 (Ser33) Antibody (AY0326)
UniProt:P15927
Application:WB,ELISA
Reactivity:Human:S33,Mouse:S33,Rat:S33
Source:Rabbit pAbhttp://www.abways.cn/showproduct.asp?cid=AY0326
数据表
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UniProt
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Mol Weight32kDa
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Alternative NamesREPA2; replication factor-A protein 2; replication protein A 32 kDa subunit; replication protein A2; RF-A; RP-A; RPA2; RPA32
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ImmunogenThe antiserum was produced against synthesized phosphopeptide derived from human RFA2 around the phosphorylation site of serine 33 (A-P-SP-Q-A).
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityPolyclonal
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DescriptionAs part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation.
Applications
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ReactivityHuman:S33,Mouse:S33,Rat:S33
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ApplicationWB,ELISA
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Recommended dilutionWB: 1:500~1:3000 ELISA: 1:10000
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Western blot analysis of extracts from 3T3 cells, treated with Adriamycin (0.5ug/ml, 24hours), using RFA2 (Phospho-Ser33) antibody.
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