Phospho-IREB1 (Ser711) Antibody
Source: Rabbit pAb Catalog No. : AY0360
Phospho-IREB1 (Ser711) Antibody (AY0360)
UniProt:P21399
Application:WB,IHC,ELISA
Reactivity:Human:S711,Mouse:S711,Rat:S711
Source:Rabbit pAbhttp://www.abways.cn/showproduct.asp?cid=AY0360
数据表
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UniProt
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Mol Weight98 Kda
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Alternative NamesACO1, Aconitate hydratase, EC 4.2.1.3, Ferritin repressor protein, IRE-BP 1, IRE1, IREBP1, IRP1, aconitase, citrate hydro-lyase, iron regulatory protein 1, iron-responsive element binding protein 1
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ImmunogenThe antiserum was produced against synthesized phosphopeptide derived from human IREB1 around the phosphorylation site of serine 711 (Y-G-SP-R-R).
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityPolyclonal
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DescriptionIron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.
Applications
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ReactivityHuman:S711,Mouse:S711,Rat:S711
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ApplicationWB,IHC,ELISA
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Recommended dilutionWB: 1:500~1:3000 IHC: 1:50~1:100 ELISA: 1:10000
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Western blot analysis of extracts from 293 cells, treated with insulin (0.01U/ml, 30mins), using IREB1 (Phospho-Ser711) antibody. -
Immunohistochemistry analysis of paraffin-embedded human thyroid gland tissue using IREB1 (Phospho-Ser711) antibody.
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