Caspase 3 (Cleaved-Asp175) Antibody
Source: Rabbit pAb Catalog No. : AY0458
Caspase 3 (Cleaved-Asp175) Antibody (AY0458)
UniProt:P42574
Application:WB,IHC
Reactivity:Human:D175,Mouse:D175,Rat:D175
Source:Rabbit pAbhttp://www.abways.cn/showproduct.asp?cid=AY0458
数据表
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UniProt
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Mol Weight17kDa
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Alternative NamesApopain precursor, CASP-3, CPP-32, CPP32, Caspase-3, Cysteine protease CPP32, ICE3, SCA-1, SREBP cleavage activity 1, Yama protein
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ImmunogenA synthesized peptide derived from human Caspase 3
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityPolyclonal
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DescriptionCaspase-3 (CPP-32, Apoptain, Yama, SCA-1) is a critical executioner of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins, such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP) (1). Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 fragments.
Applications
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ReactivityHuman:D175,Mouse:D175,Rat:D175
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ApplicationWB,IHC
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Recommended dilutionWB: 1:500~1:3000 IHC: 1:50~1:100 ELISA: 1:20000
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Western blot analysis of extracts from 293 cells, treated with Etoposide (25uM, 60mins), using Caspase 3 (cleaved-Asp175) antibody. -
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue, using Caspase 3 (cleaved-Asp175) antibody.
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