Q02156

84 kDa

EC 2.7.11.13, KPCE, PKC-epsilon, PKCEA, PRKCE, Protein kinase C, epsilon type, kinase PKC-epsilon, nPKC-epsilon

The antiserum was produced against synthesized phosphopeptide derived from human PKC ε around the phosphorylation site of serine 729 (G-F-SP-Y-F).

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Affinity-chromatography

Rabbit IgG

Polyclonal

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein.

Human:S729,Mouse:S729,Rat:S729,

WB,ELISA

WB: 1:500~1:3000 ELISA: 1:10000