Phospho-Bax (Ser184) Antibody
Source: Rabbit pAb Catalog No. : AY0638
Phospho-Bax (Ser184) Antibody (AY0638)
UniProt:Q07812
Application:WB,IHC,ELISA
Reactivity:Human:S184,Mouse:S184,Rat:S184
Source:Rabbit pAbhttp://www.abways.cn/showproduct.asp?cid=AY0638
数据表
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UniProt
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Mol Weight21 kDa
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Alternative NamesApoptosis regulator BAX, membrane isoform alpha; BAXA; Bcl2-associated X protein
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ImmunogenThe antiserum was produced against synthesized phosphopeptide derived from human Bax around the phosphorylation site of serine 184 (T-A-SP-L-T).
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityPolyclonal
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DescriptionBax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9 and initiation of the caspase activation pathway for apoptosis.
Applications
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ReactivityHuman:S184,Mouse:S184,Rat:S184
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ApplicationWB,IHC,ELISA
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Recommended dilutionWB: 1:500~1:3000 IHC: 1:50~1:100 ELISA: 1:10000
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Western blot analysis of extracts from K562 cells, using Bax (Phospho-Ser184) antibody. -
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Bax (Phospho-Ser184) antibody.
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