Bax Antibody
Source: Rabbit pAb Catalog No. : CY1006
Bax Antibody (CY1006)
UniProt:Q07812
Application:WB,IHC,IF
Reactivity:Human,Mouse,Rat
Source:Rabbit pAb
References（2）
http://www.abways.cn/showproduct.asp?cid=CY1006
数据表
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UniProt
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Mol Weight21kDa
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Alternative NamesApoptosis regulator BAX; BAX; Bcl-2-like protein 4; BCL2-associated X protein; Bcl2-L-4; BCL2L4
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ImmunogenA synthesized peptide derived from human Bax
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityPolyclonal
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DescriptionBax Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Induces the release of cytochrome c, activation of CASP3, and thereby apoptosis. Belongs to the Bcl-2 family. Homodimer. Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Isoform Sigma interacts with BCL2A1 and BCL2L1 isoform Bcl-X(L). 8 isoforms of the human protein are produced by alternative splicing.
Applications
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ReactivityHuman,Mouse,Rat
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ApplicationWB,IHC,IF
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Recommended dilutionWB 1:500~1:2000 IHC 1:50~1:200 IF 1:50~1:200
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Western blot analysis of extracts from 293 cells, using BAX antibody. -
Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using BAX antibody. -
Immunofluorescence analysis of HUVEC cells, using BAX antibody.
引用文献（2条）
Inhibition of B7-H4 promotes hepatocellular carcinoma cell apoptosis and autophagy through the PI3K signaling pathway-International Immunopharmacology (INT IMMUNOPHARMACOL)
Circadian gene Clock participates in mitochondrial apoptosis pathways by regulating mitochondrial membrane potential, mitochondria out membrane permeablization and apoptosis factors in AML12 hepatocytes-Molecular and Cellular Biochemistry (MOL CELL BIOCHE
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