Cullin 2 Antibody
Source: Rabbit pAb Catalog No. : CY1025
Cullin 2 Antibody (CY1025)
UniProt:Q13617
Application:WB,IHC,ICC/IF
Reactivity:Human,Mouse
Source:Rabbit pAbhttp://www.abways.cn/showproduct.asp?cid=CY1025
数据表
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UniProt
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Mol Weight87kDa
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Alternative NamesCUL-2; CUL2; cullin 2; Cullin-2; MGC131970
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ImmunogenA synthesized peptide derived from human Cullin 2
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityPolyclonal
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DescriptionCUL2 Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
Applications
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ReactivityHuman,Mouse
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ApplicationWB,IHC,ICC/IF
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Recommended dilutionWB 1:500~1:3000 IHC 1:50~1:200 IF/ICC 1:100~1:500
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Western blot analysis of extracts from LOVO cells, using Cullin 2 antibody. -
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Cullin 2 antibody. -
Immunofluorescence analysis of NIH/3T3 cells, using Cullin 2 antibody. -
Western blot analysis of extracts from HepG2 cells, using Cullin 2 antibody.
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