Parkin Antibody
Source: Rabbit pAb Catalog No. : CY1241
Parkin Antibody (CY1241)
UniProt:O60260
Application:WB,IHC
Reactivity:Human,Mouse,Rat
Source:Rabbit pAbhttp://www.abways.cn/showproduct.asp?cid=CY1241
数据表
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UniProt
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Mol Weight52kDa
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Alternative NamesAR-JP; E3 ubiquitin ligase; E3 ubiquitin-protein ligase parkin; LPRS2; PARK2; parkin; parkin 2; Parkinson disease (autosomal recessive, juvenile) 2, parkin; Parkinson disease protein 2; Parkinson juvenile disease protein 2; PDJ; PRKN; PRKN2
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ImmunogenA synthesized peptide derived from human Parkin
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityPolyclonal
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DescriptionPARK2 Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5 and AIMP2. May play a more general role in the ubiquitin proteasomal pathway by participating in the removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of PARK2.
Applications
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ReactivityHuman,Mouse,Rat
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ApplicationWB,IHC
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Recommended dilutionWB 1:500~1:3000 IHC 1:50~1:200
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Western blot analysis of extracts from Jukat cells, using Parkin antibody.
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