active Caspase-3 Antibody
Source: Rabbit mAb Catalog No. : CY5031
active Caspase-3 Antibody (CY5031)
UniProt:P42574
Application:WB,IHC,ICC/IF
Reactivity:Human
Source:Rabbit mAb
References（6）
http://www.abways.cn/showproduct.asp?cid=CY5031
数据表
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UniProt
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Mol Weight17kDa
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Alternative NamesApopain precursor; Cysteine protease CPP32; ICE3; CASP-3; CPP32; Caspase-3; SCA-1;
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ImmunogenA synthesized peptide derived from human active Caspase-3
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityMonoclonal
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DescriptionSequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.
Applications
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ReactivityHuman
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ApplicationWB,IHC,ICC/IF
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Recommended dilutionWB 1:500~1:2000 IHC 1:50~1:100 ICC/IF 1:50~1:100
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Western blot analysis of active Caspase-3 expression in Jurkat cell lysate treated with Camptothecin. -
Immunofluorescent analysis of HepG2 cells, using active Caspase-3 Antibody . -
Combination of novel DR5 targeting agonistic scFv antibody TR2-3 with cisplatin shows enhanced synergistic antitumor activity in vitro and in vivo. -Biomedicine & Pharmacotherapy
引用文献（6条）
Cytidine monophosphate kinase is inhibited by the TGF-β signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer.-Cellular Signalling
Combination of novel DR5 targeting agonistic scFv antibody TR2-3 with cisplatin shows enhanced synergistic antitumor activity in vitro and in vivo.-Biomedicine & Pharmacotherapy
Salidroside induces apoptosis and protective autophagy in human gastric cancer AGS cells through the PI3K/Akt/mTOR pathway-Biomedicine & Pharmacotherapy (BIOMED PHARMACOTHER)
Ivermectin induces apoptosis of esophageal squamous cell carcinoma via mitochondrial pathway-BMC Cancer
Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma-INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Int. J. Mol. Sci)
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