Notch1 Antibody
Source: Rabbit mAb Catalog No. : CY5244
Notch1 Antibody (CY5244)
UniProt:P46531
Application:WB,IHC,ICC/IF,FC
Reactivity:Human,Mouse
Source:Rabbit mAb
References（1）
http://www.abways.cn/showproduct.asp?cid=CY5244
数据表
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UniProt
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Mol Weight125kDa
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Alternative NamesNOTC1, NOTCH1, TAN1, hN1, neurogenic locus notch homolog protein 1, neurogenic locus notch homolog protein 1 precursor,
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ImmunogenA synthesized peptide derived from human Notch1
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityMonoclonal
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DescriptionFunctions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.
Applications
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ReactivityHuman,Mouse
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ApplicationWB,IHC,ICC/IF,FC
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Recommended dilutionWB 1:500~1:3000 IHC 1:50~1:200 ICC/IF 1:100~1:500 FC 1:200~1:500
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All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature. -
Immunofluorescent analysis using the Antibody at 1:50 dilution. -
Western blot analysis of NOTCH1 expression in HEK293 cell lysate. -
Immunohistochemical analysis of paraffin-embedded human liver, using Notch1 Antibody . -
Immunofluorescent analysis of HeLa cells, using Notch1 Antibody .
引用文献（1条）
FSTL1 suppresses tumor cell proliferation, invasion and survival in non-small cell lung cancer.-ONCOLOGY REPORTS
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