Phospho-Retinoblastoma (S780) Antibody
Source: Rabbit mAb Catalog No. : CY5260
Phospho-Retinoblastoma (S780) Antibody (CY5260)
UniProt:P06400
Application:WB,IHC
Reactivity:Human
Source:Rabbit mAb
References（1）
http://www.abways.cn/showproduct.asp?cid=CY5260
数据表
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UniProt
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Mol Weight110kDa
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Alternative NamesOSRC; RB; p105-Rb; pRb; RB1; pp110; Retinoblastoma 1; PPP1R130
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ImmunogenA synthesized peptide derived from human Retinoblastoma
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityMonoclonal
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DescriptionCell cycle-dependent phosphorylation by a CDK inhibits Rb target binding and allows cell cycle progression. Rb inactivation and subsequent cell cycle progression likely requires an initial phosphorylation by cyclin D-CDK4/6 followed by cyclin E-CDK2 phosphorylation. Specificity of different CDK/cyclin complexes has been observed in vitro and cyclin D1 is required for Ser780 phosphorylation in vivo.
Applications
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ReactivityHuman
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ApplicationWB,IHC
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Recommended dilutionWB 1:500~1:2000 IHC 1:50~1:200
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Western blot analysis of Retinoblastoma phosphorylation expression in Jurkat cell lysate treated with Alkaline Phosphatase.
引用文献（1条）
Down-regulation of RCC1 sensitizes immunotherapy by up-regulating PD-L1 via p27kip1/CDK4 axis in non-small cell lung cancer-JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (J CELL MOL MED)
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