Phospho-Erk1 (T202/Y204) + Erk2 (T185/Y187) Antibody_单克隆抗体-上海泊湾生物技术有限公司

Phospho-Erk1 (T202/Y204) + Erk2 (T185/Y187) Antibody

Source: Rabbit mAb Catalog No. : CY5277

Phospho-Erk1 (T202/Y204) + Erk2 (T185/Y187) Antibody (CY5277)
UniProt:P27361/P28482
Application:WB,IP
Reactivity:Human,Mouse,Rat
Source:Rabbit mAb
References（17）
http://www.abways.cn/showproduct.asp?cid=CY5277

 Datasheet

数据表

UniProt

P27361/P28482
Mol Weight

42kDa，44kDa
Alternative Names

ERK-1; ERK1; ERT2; kinase ERK1; MAP kinase 1; MAPK 1; MAPK3; MK03; MNK1; p44-ERK1; P44-ERK1; p44-MAPK;
Immunogen

A synthesized peptide derived from human Phospho-ERK1 (Y204) + ERK2 (Y187)
Storage

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Purification

Affinity-chromatography
Isotype

Rabbit IgG
Clonality

Monoclonal
Description

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements.

Applications

Reactivity

Human,Mouse,Rat
Application

WB,IP
Recommended dilution

WB 1:500~1:2000 IP 1:50

All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
Western blot analysis of Phospho-Erk1 (T202/Y204) + Erk2 (T185/Y187) expression in A431 cell lysate treated with EGF.
Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling
Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling. -Cell Death & Disease
Polysaccharides from Nostoc commune Vaucher activate macrophages via NF-κB and AKT/JNK1/2 pathways to suppress colorectal cancer growth in vivo. -Food & Function
Critical role for non‑GAP function of Gαs in RGS1‑mediated promotion of melanoma progression through AKT and ERK phosphorylation. -Oncology Reports
CircDLST promotes the tumorigenesis and metastasis of gastric cancer by sponging miR-502-5p and activating the NRAS/MEK1/ERK1/2 signaling. -Molecular Cancer

引用文献（17条）

Critical role for non‑GAP function of Gαs in RGS1‑mediated promotion of melanoma progression through AKT and ERK phosphorylation.-Oncology Reports

Euphorbia factor L2 alleviates lipopolysaccharide-induced acute lung injury and inflammation in mice through the suppression of NF-κB activation.-Biochemical Pharmacology

Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling.-Cell Death & Disease

CircDLST promotes the tumorigenesis and metastasis of gastric cancer by sponging miR-502-5p and activating the NRAS/MEK1/ERK1/2 signaling.-Molecular Cancer

Polysaccharides from Nostoc commune Vaucher activate macrophages via NF-κB and AKT/JNK1/2 pathways to suppress colorectal cancer growth in vivo.-Food & Function

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