Cathepsin D Antibody
Source: Rabbit mAb Catalog No. : CY5339
Cathepsin D Antibody (CY5339)
UniProt:P07339
Application:WB,IHC,ICC/IF,IP,FC
Reactivity:Human,Mouse,Rat
Source:Rabbit mAb
References（3）
http://www.abways.cn/showproduct.asp?cid=CY5339
数据表
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UniProt
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Mol Weight46kDa/28kDa
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Alternative NamesCATD; Cathepsin D; Cathepsin D heavy chain; Cathepsin D light chain; ceroid-lipofuscinosis, neuronal 10; CLN10; CPSD; CTSD; lysosomal aspartyl peptidase; lysosomal aspartyl protease; MGC2311
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ImmunogenA synthesized peptide derived from human Cathepsin D
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityMonoclonal
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DescriptionThis gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.
Applications
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ReactivityHuman,Mouse,Rat
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ApplicationWB,IHC,ICC/IF,IP,FC
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Recommended dilutionWB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50 FC 1:20
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All lanes use the Antibody at 1:2W dilution for 1 hour at room temperature. -
All lanes use the Antibody at 1:2W dilution for 1 hour at room temperature. -
Western blot analysis of Cathepsin D expression in (1)MCF-7 cell lysate;(2)SKBR-3 cell lysate. -
Immunohistochemical analysis of paraffin-embedded human ovarian cancer, using Cathepsin D Antibody. -
All lanes use the Antibody at 1:1k dilution for 1 hour at room temperature.
引用文献（3条）
TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation-Autophagy (AUTOPHAGY)
Swainsonine promotes apoptosis by impairing lysosomal function and inhibiting autophagic degradation in rat primary renal tubular epithelial cells-Chemico-Biological Interactions (CHEM-BIOL INTERACT)
Swainsonine inhibits autophagic degradation and causes cytotoxicity by reducing CTSD O-GlcNAcylation-CHEMICO-BIOLOGICAL INTERACTIONS
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