LGR5/GPR49 Antibody
Source: Rabbit mAb Catalog No. : CY5369
LGR5/GPR49 Antibody (CY5369)
UniProt:O75473
Application:WB,IP,FC
Reactivity:Human,Mouse,Rat
Source:Rabbit mAb
References（1）
http://www.abways.cn/showproduct.asp?cid=CY5369
数据表
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UniProt
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Mol Weight100kDa
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Alternative NamesFEX; GPR49; GPR67; GRP49; LGR5; HG38;8
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ImmunogenA synthesized peptide derived from human LGR5/GPR49
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityMonoclonal
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DescriptionReceptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.
Applications
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ReactivityHuman,Mouse,Rat
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ApplicationWB,IP,FC
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Recommended dilutionWB 1:500~1:2000 IP 1:50 FC 1:200
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Western blot analysis of GPR49 expression in Human fetal skeletal muscle lysate. -
All lanes use the Antibody at 1:6K dilution for 1 hour at room temperature.
引用文献（1条）
REC8 enhances stemness and promotes metastasis of colorectal cancer through BTK/Akt/β-catenin signaling pathway-Translational Oncology (TRANSL ONCOL）
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