VDAC1 Antibody
Source: Rabbit mAb Catalog No. : CY5416
VDAC1 Antibody (CY5416)
UniProt:P21796
Application:WB,IHC,ICC/IF
Reactivity:Human,Mouse,Rat
Source:Rabbit mAb
References（6）
http://www.abways.cn/showproduct.asp?cid=CY5416
数据表
-
UniProt
-
Mol Weight31kDa
-
Alternative NamesVDAC1;MGC111064;PORIN;PORIN-31-HL;
-
ImmunogenA synthesized peptide derived from human VDAC1
-
StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
-
PurificationAffinity-chromatography
-
IsotypeRabbit IgG
-
ClonalityPolyclonal
-
DescriptionVoltage-dependent anion channel (VDAC), ubiquitously expressed and located in the outer mitochondrial membrane, is generally thought to be the primary means by which metabolites diffuse in and out of the mitochondria (1). In addition, this channel plays a role in apoptotic signaling. The change in mitochondrial permeability characteristic of apoptosis is mediated by Bcl-2 family proteins, which bind to VDAC, altering the channel kinetics (2). Homodimerization of VDAC may be a mechanism for changing mitochondrial permeability and supporting release of cytochrome c (3). In mammalian cells, there are three VDAC isoforms, VDAC1, which is the most widely expressed isoform, as well as VDAC2 and VDAC3 (4,5).
Applications
-
ReactivityHuman,Mouse,Rat
-
ApplicationWB,IHC,ICC/IF
-
Recommended dilutionWB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200
-
All lanes use the Antibody at 1:2W dilution for 1 hour at room temperature. -
All lanes use the Antibody at 1:2W dilution for 1 hour at room temperature. -
Immunohistochemical analysis of paraffin-embedded Mouse intestine, using the Antibody at 1:1000 dilution. -
Immunohistochemical analysis of paraffin-embedded Mouse skin, using the Antibody at 1:1000 dilution. -
Immunohistochemical analysis of paraffin-embedded Human stomach, using the Antibody at 1:2000 dilution. -
Immunohistochemical analysis of paraffin-embedded Human prostate cancer, using the Antibody at 1:2000 dilution. -
Immunofluorescent analysis using the Antibody at 1:50 dilution. -
Western blot analysis of VDAC1 expression in (1) HepG2 cell lysate; (2) Jurkat cell lysate.
引用文献（6条）
Berberine Reduces Pyruvate-driven Hepatic Glucose Production by Limiting Mitochondrial Import of Pyruvate through Mitochondrial Pyruvate Carrier 1.-EBioMedicine
The crosstalk between mitochondrial dysfunction and endoplasmic reticulum stress promoted ATF4-mediated mitophagy induced by hexavalent chromium-Environmental Toxicology (ENVIRON TOXICOL)
Melatonin enhances SIRT1 to ameliorate mitochondrial membrane damage by activating PDK1/Akt in granulosa cells of PCOS-Journal of Ovarian Research (J OVARIAN RES)
Cr (VI) induced mitophagy via the interaction of HMGA2 and PARK2-Toxicology Letters (TOXICOL LETT)
Salmonella Induces the cGAS-STING-Dependent Type I Interferon Response in Murine Macrophages by Triggering mtDNA Release-mBio
销售咨询
一键电话