Fibrillarin Antibody
Source: Rabbit mAb Catalog No. : CY5512
Fibrillarin Antibody (CY5512)
UniProt:P22087
Application:WB,IHC,ICC/IF,IP,FC
Reactivity:Human,Mouse,Rat
Source:Rabbit mAb
References（1）
http://www.abways.cn/showproduct.asp?cid=CY5512
数据表
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UniProt
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Mol Weight33kDa
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Alternative NamesFBL;FIB;FLRN;RNU3IP1;
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ImmunogenA synthesized peptide derived from human Fibrillarin
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityMonoclonal
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DescriptionFibrillarin is a 2'-O-methyltransferase located in fibrillar regions and Cajal bodies of the nucleolus, where RNA transcription and pre-RNA processing take place. Fibrillarin associates with several other structual proteins as well as box C/D snoRNA to form a complex that functions in pre-rRNA processing, pre-rRNA methylation and ribosome assembly. This complex catalyzes site-specific 2'-O-ribose methylation of targeted nucleotides within the rRNA sequence. The sequence, structure and function of fibrillarin are highly conserved and fibrillarin gene expression is essential for early embryonic development.
Applications
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ReactivityHuman,Mouse,Rat
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ApplicationWB,IHC,ICC/IF,IP,FC
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Recommended dilutionWB 1:500~1:2000 IHC 1:50~1:100 ICC/IF 1:50~1:100 IP : 1:30 FC 1:50
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All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature. -
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature. -
Immunofluorescent analysis using the Antibody at 1:50 dilution. -
Western blot analysis of Fibrillarin expression in HepG2 cell lysate. -
Immunohistochemical analysis of paraffin-embedded human testis, using Fibrillarin Antibody. -
Immunofluorescent analysis of Hela cells, using Fibrillarin Antibody .
引用文献（1条）
LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice-J Vet Sci (Journal of Veterinary Science)
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