p21 Antibody
Source: Rabbit mAb Catalog No. : CY5543
p21 Antibody (CY5543)
UniProt:P38936
Application:WB,ICC/IF
Reactivity:Human,Mouse,Rat
Source:Rabbit mAb
References（5）
http://www.abways.cn/showproduct.asp?cid=CY5543
数据表
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UniProt
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Mol Weight21kDa
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Alternative NamesCAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1
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ImmunogenA synthesized peptide derived from human p21
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityMonoclonal
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DescriptionThe tumor suppressor protein p21 Waf1/Cip1 acts as an inhibitor of cell cycle progression. It functions in stoichiometric relationships forming heterotrimeric complexes with cyclins and cyclin-dependent kinases. In association with CDK2 complexes, it serves to inhibit kinase activity and block progression through G1/S. However, p21 may also enhance assembly and activity in complexes of CDK4 or CDK6 and cyclin D.
Applications
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ReactivityHuman,Mouse,Rat
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ApplicationWB,ICC/IF
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Recommended dilutionWB 1:500~1:2000 ICC/IF 1:50~1:200
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Immunofluorescent analysis using the Antibody at 1:150 dilution. -
Western blot analysis of p21 in (1) MCF-7 cell lysate; (2) HeLa cell lysate. (3) LnCap cell lysate; (4) U87 MG cell lysate. -
Immunofluorescent analysis of MCF7 cells, using p21 Antibody. -
Fibulin-3 has anti-tumorigenic activities in cutaneous squamous cell carcinoma. -Journal of Investigative Dermatology -
All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
引用文献（5条）
Fibulin-3 has anti-tumorigenic activities in cutaneous squamous cell carcinoma.-Journal of Investigative Dermatology
Autolysosomal degradation of cytosolic chromatin fragments antagonizes oxidative stress stress–induced senescence-Molecular Cell (MOL CELL)
E47 upregulates ΔNp63α to promote growth of squamous cell carcinoma-Cell Death & Disease (CELL DEATH DIS)
Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice-Journal of the American Heart Association (J AM HEART ASSOC)
AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/STAT3 axis-mediated positive feedback loop-Mechanisms of Ageing and Development (MECH AGEING DEV)
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