p62/SQSTM1 Antibody
Source: Rabbit mAb Catalog No. : CY5546
p62/SQSTM1 Antibody (CY5546)
UniProt:Q13501
Application:WB,ICC/IF,FC,IP
Reactivity:Human,Mouse,Rat
Source:Rabbit mAb
References（18）
http://www.abways.cn/showproduct.asp?cid=CY5546
数据表
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UniProt
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Mol Weight62kDa
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Alternative NamesOSIL; Oxidative stress induced like; p60; p62; p62B; Paget disease of bone 3;PDB 3; PDB3;
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ImmunogenA synthesized peptide derived from human p62/SQSTM1
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityMonoclonal
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DescriptionAutophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1.
Applications
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ReactivityHuman,Mouse,Rat
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ApplicationWB,ICC/IF,FC,IP
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Recommended dilutionWB 1:5000~1:10000 ICC/IF 1:50~1:200 IP 1:50 FC 1:50
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All lanes use the Antibody at 1:3W dilution for 1 hour at room temperature. -
All lanes use the Antibody at 1:3W dilution for 1 hour at room temperature. -
All lanes use the Antibody at 1:3W dilution for 1 hour at room temperature. -
All lanes use the Antibody at 1:3W dilution for 1 hour at room temperature. -
All lanes use the Antibody at 1:3W dilution for 1 hour at room temperature. -
Immunofluorescent analysis using the Antibody at 1:50 dilution. -
Western blot analysis of p62/SQSTM1 expression in SKBR-3 cell lysate. -
Immunofluorescent analysis of Hela cells, using p62/SQSTM1 Antibody. -
Pyrroloquinoline quinine ameliorates doxorubicin-induced autophagy-dependent apoptosis via lysosomal-mitochondrial axis in vascular endothelial cells. -Toxicology -
Prostaglandin E1 Inhibited Diabetes-Induced Phenotypic Switching of Vascular Smooth Muscle Cells Through Activating Autophagy. -Cellular Physiology and Biochemistry -
MicroRNA-199a acts as a potential suppressor of cardiomyocyte autophagy through targeting Hspa5. -Oncotarget
引用文献（18条）
MicroRNA-199a acts as a potential suppressor of cardiomyocyte autophagy through targeting Hspa5.-Oncotarget
Prostaglandin E1 Inhibited Diabetes-Induced Phenotypic Switching of Vascular Smooth Muscle Cells Through Activating Autophagy.-Cellular Physiology and Biochemistry
Acrolein induces NLRP3 inflammasome-mediated pyroptosis and suppresses migration via ROS-dependent autophagy in vascular endothelial cells.-Toxicology
Dual receptor recognizing liposomes containing paclitaxel and hydroxychloroquine for primary and metastatic melanoma treatment via autophagy-dependent and independent pathways.-Journal of Controlled Release
Size-Adjustable Micelles Co-loaded with Chemotherapeutic Agent and Autophagy Inhibitor for Enhancing Cancer Treatment via Increasing Tumor Retention.-Acta Biomaterialia
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