PIM1 Antibody
Source: Rabbit mAb Catalog No. : CY5556
PIM1 Antibody (CY5556)
UniProt:P11309
Application:WB,IHC,ICC/IF
Reactivity:Human,Mouse
Source:Rabbit mAbhttp://www.abways.cn/showproduct.asp?cid=CY5556
数据表
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UniProt
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Mol Weight32kDa
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Alternative NamesOncogene PIM1; PIM; pim-1 kinase 44 kDa isoform; pim-1 oncogene; pim-1 oncogene (proviral integration site 1); PIM1;
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ImmunogenA synthesized peptide derived from human PIM1
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityMonoclonal
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DescriptionPim1 a proto-oncogene serine/threonine kinase involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerced by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis.
Applications
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ReactivityHuman,Mouse
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ApplicationWB,IHC,ICC/IF
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Recommended dilutionWB 1:5000~1:10000 IHC 1:50~1:200 ICC/IF 1:50~1:200
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All lanes use the Antibody at 1:3K dilution for 1 hour at room temperature. -
All lanes use the Antibody at 1:3K dilution for 1 hour at room temperature. -
Western blot analysis of PIM1 expression in Jurkat cell lysate. -
Immunohistochemical analysis of paraffin-embedded human prostate carcinoma, using PIM1 Antibody .
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