P25963

39kDa

I-kappa-B-alpha; IKBA; IkappaBalpha; MAD3; NFKBI; NFKBIA; RL/IF-1;

A synthesized peptide derived from human Phospho-IKB alpha (S32)

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Affinity-chromatography

Rabbit IgG

Monoclonal

Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB. IκBα phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified.

Human

WB,IP

WB 1:500~1:2000 IP 1:50