TPH1 Antibody
Source: Rabbit mAb Catalog No. : CY5574
TPH1 Antibody (CY5574)
UniProt:P17752
Application:WB,IHC,IP
Reactivity:Human,Mouse,Rat
Source:Rabbit mAb
References（2）
http://www.abways.cn/showproduct.asp?cid=CY5574
数据表
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UniProt
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Mol Weight51kDa
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Alternative NamesTPH1;MGC119994;TPRH;TRPH;Tryptophan 5-hydroxylase 1; Tryptophan Hydroxylase;
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ImmunogenA synthesized peptide derived from human TPH1
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityMonoclonal
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DescriptionTryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin by converting tryptophan to 5-hydroxy-L-tryptophan. Two isoforms of TPH exist: TPH-1 is mainly expressed in the periphery, whereas the expression of TPH-2 is restricted to neuronal cells and the central nervous system. Most of the serotonin found throughout the body is synthesized by TPH-1 in enterochromaffin cells of the gastrointestinal tract. Targeted disruption of the tph1 gene results in low levels of circulating and tissue serotonin.
Applications
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ReactivityHuman,Mouse,Rat
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ApplicationWB,IHC,IP
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Recommended dilutionWB 1:500~1:2000 IHC 1:50~1:200 IP 1:50
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All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature. -
Western blot analysis of TPH1 expression in THP-1 cell lysate.
引用文献（2条）
Fecal Microbiome Transplantation from Children with Autism Spectrum Disorder Modulates Tryptophan and Serotonergic Synapse Metabolism and Induces Altered Behaviors in Germ-Free Mice-mSystems
Maternal LPS Exposure Enhances the 5-HT Level in the Prefrontal Cortex of Autism-like Young Offspring-Brain Sciences
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