Phospho-IRE1 (S724) Antibody
Source: Rabbit mAb Catalog No. : CY5605
Phospho-IRE1 (S724) Antibody (CY5605)
UniProt:O75460
Application:WB
Reactivity:Human
Source:Rabbit mAb
References（3）
http://www.abways.cn/showproduct.asp?cid=CY5605
数据表
-
UniProt
-
Mol Weight110kDa
-
Alternative NamesERN1, ER to nucleus signalling 1, Inositol-requiring enzyme 1, Inositol-requiring protein 1, Ire1-alpha, IRE1a, HIRE1p, IRE1, Inositol-requiring 1, IRE1P;
-
ImmunogenA synthesized peptide derived from human Phospho-IRE1 (S724)
-
StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
-
PurificationAffinity-chromatography
-
IsotypeRabbit IgG
-
ClonalityMonoclonal
-
DescriptionSenses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Applications
-
ReactivityHuman
-
ApplicationWB
-
Recommended dilutionWB 1:500~1:2000
-
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature. -
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature. -
Western blot analysis of Phospho-IRE1 (S724) expression in (1) K562 cell lysate treated with AP; (2) Untreated K562 cell lysate.
引用文献（3条）
Induction of the Unfolded Protein Response during Bovine Alphaherpesvirus 1 Infection-viruses (Viruses-Basel VIRUSES-BASEL)
Swainsonine Triggers Paraptosis via ER Stress and MAPK Signaling Pathway in Rat Primary Renal Tubular Epithelial Cells-Frontiers in Pharmacology (FRONT PHARMACOL)
CHOP Regulates Endoplasmic Reticulum Stress-Mediated Hepatoxicity Induced by Monocrotaline-Frontiers in Pharmacology (Front. Pharmacol)
销售咨询
一键电话