Phospho-Tau (S396) Antibody
Source: Rabbit mAb Catalog No. : CY5657
Phospho-Tau (S396) Antibody (CY5657)
UniProt:P10636
Application:WB,IHC
Reactivity:Human,Mouse,Rat
Source:Rabbit mAbhttp://www.abways.cn/showproduct.asp?cid=CY5657
数据表
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UniProt
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Mol Weight50-80kDa
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Alternative NamesMAPT; Microtubule-associated protein tau; MTBT1; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau;
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ImmunogenA synthesized peptide derived from human Phospho-Tau (S396)
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityMonoclonal
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DescriptionTau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 . Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau.
Applications
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ReactivityHuman,Mouse,Rat
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ApplicationWB,IHC
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Recommended dilutionWB 1:10000~1:20000 IHC1:100~1:500
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All lanes use the Antibody at 1:4k dilution for 1 hour at room temperature. -
Western blot analysis of Phospho-Tau (S396) expression in (1) SH-SY5Y cell lysate treated with AP; (2) SH-SY5Y cell lysate. -
Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using Phospho-Tau (S396) Antibody.
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