Phospho-Chk1 (S296) Antibody
Source: Rabbit mAb Catalog No. : CY5677
Phospho-Chk1 (S296) Antibody (CY5677)
UniProt:O14757
Application:WB
Reactivity:Human
Source:Rabbit mAbhttp://www.abways.cn/showproduct.asp?cid=CY5677
数据表
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UniProt
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Mol Weight54kDa
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Alternative NamesCheckpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog (S. pombe); Serine/threonine-protein kinase Chk1;
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ImmunogenA synthesized peptide derived from human Phospho-Chk1 (S296)
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityMonoclonal
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DescriptionChk1 kinase acts downstream of ATM/ATR kinase and plays an important role in DNA damage checkpoint control, embryonic development, and tumor suppression. Activation of Chk1 involves phosphorylation at Ser317 and Ser345 by ATM/ATR, followed by autophosphorylation of Ser296. Activation occurs in response to blocked DNA replication and certain forms of genotoxic stress.
Applications
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ReactivityHuman
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ApplicationWB
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Recommended dilutionWB 1:500~1:2000
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Western blot analysis of Phospho-Chk1 (S296) expression in HEK293 cell lysate Treated with Calyculin.
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