cleaved Caspase-9 Antibody
Source: Rabbit mAb Catalog No. : CY5682
cleaved Caspase-9 Antibody (CY5682)
UniProt:P55211
Application:WB,IP
Reactivity:Human,Mouse
Source:Rabbit mAb
References（6）
http://www.abways.cn/showproduct.asp?cid=CY5682
数据表
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UniProt
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Mol Weight46,39,37,35kDa
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Alternative NamesMCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; CASP9; Caspase-9; Caspase 9 Dominant Negative;
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ImmunogenA synthesized peptide derived from human cleaved Caspase-9
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityMonoclonal
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DescriptionInvolved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
Applications
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ReactivityHuman,Mouse
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ApplicationWB,IP
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Recommended dilutionWB 1:500~1:2000 IP 1:50
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All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature. -
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature. -
Western blot analysis of cleaved Caspase-9 Antibody expression in HeLa cell lysate treated with staurosporine. -
EMP3, which is regulated by miR-663a, suppresses gallbladder cancer progression via interference with the MAPK/ERK pathway. -Cancer Letters -
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
引用文献（6条）
Salidroside induces apoptosis and protective autophagy in human gastric cancer AGS cells through the PI3K/Akt/mTOR pathway-Biomedicine & Pharmacotherapy (BIOMED PHARMACOTHER)
CircRNA8220 Sponges MiR-8516 to Regulate Cell Viability and Milk Synthesis via Ras/MEK/ERK and PI3K/AKT/mTOR Pathways in Goat Mammary Epithelial Cells-Animals
Ivermectin induces apoptosis of esophageal squamous cell carcinoma via mitochondrial pathway-BMC Cancer
Aloe-emodin induces autophagy and apoptotic cell death in non-small cell lung cancer cells via Akt/mTOR and MAPK signaling-European Journal of Pharmacology (EUR J PHARMACOL)
Mesenchymal stem cells combined with liraglutide relieve acute lung injury through apoptotic signaling restrained by PKA/β-catenin-Stem Cell Research & Therapy (STEM CELL RES THER)
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