Q9UBN7

160kDa

HD 6; HDAC 6; Histone deacetylase 6 (HD6); JM 21;

A synthesized peptide derived from human HDAC6

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Affinity-chromatography

Rabbit IgG

Monoclonal

Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases.

Human

WB,IHC,ICC/IF,IP

WB 1:5000~1:20000 IHC 1:50~1:200 ICC/IF 1:100~1:500 IP 1:50