KMT6 / EZH2 Antibody_单克隆抗体-上海泊湾生物技术有限公司

KMT6 / EZH2 Antibody

Source: Rabbit mAb Catalog No. : CY5984

KMT6 / EZH2 Antibody (CY5984)
UniProt:Q15910
Application:WB,IHC,ICC/IF,FC
Reactivity:Human,Mouse,Rat
Source:Rabbit mAb
References（1）
http://www.abways.cn/showproduct.asp?cid=CY5984

 Datasheet

数据表

UniProt

Q15910
Mol Weight

98kDa
Alternative Names

EZH 2; EZH1; EZH2; EZH2b; KMT 6; KMT6; KMT6A;
Immunogen

A synthesized peptide derived from human KMT6 / EZH2
Storage

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Purification

Affinity-chromatography
Isotype

Rabbit IgG
Clonality

Monoclonal
Description

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.

Applications

Reactivity

Human,Mouse,Rat
Application

WB,IHC,ICC/IF,FC
Recommended dilution

WB 1:500~1:1000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1：50

Western blot analysis of KMT6 / EZH2 expression in HEK293 cell lysate.
Immunohistochemical analysis of paraffin-embedded human tonsil, using KMT6 / EZH2 Antibody.
Immunofluorescent analysis of Hela cells, using KMT6 / EZH2 Antibody.
Immunofluorescent analysis using the Antibody at 1:25 dilution.

引用文献（1条）

EZH2-CCF-cGAS Axis Promotes Breast Cancer Metastasis-International Journal of Molecular Sciences