Phospho-AKT1(Thr308) Antibody
Source: Rabbit pAb Catalog No. : CY6021
Phospho-AKT1(Thr308) Antibody (CY6021)
UniProt:P31749
Application:WB
Reactivity:Human,Mouse,Rat
Source:Rabbit pAbhttp://www.abways.cn/showproduct.asp?cid=CY6021
数据表
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UniProt
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Mol Weight56-60kDa
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Alternative NamesAKT, AKT1 kinase, C-AKT, EC 2.7.11.1, PKB, PKB-alpha, Protein kinase B, RAC, RAC-PK-alpha, RAC-alpha serine/threonine kinase, kinase Akt1
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ImmunogenA synthesized peptide derived from human AKT1 around the phosphorylation site of Threonine 308
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityPolyclonal
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Descriptionan AGC kinase that plays a critical role in controlling the balance between survival and AP0ptosis. Phosphorylated and activated by PDK1 in the PI3 kinase pathway. Mediates survival signals downstream of PI3 kinase and several growth factor receptors by phosphorylating AP0pototic proteins. First found in a mouse transforming retrovirus. Tumorigenic in a mouse lymphoma model and activated (by phospho-Akt staining) and/or overexpressed in a number of cancers including breast, prostate, lung, pancreatic, liver, ovarian and colorectal. Inhibitor: RX-0201. Substrates include tuberin, Bad, Forkhead transcription factors, caspase-9, and glycogen synthase kinase-3.
Applications
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ReactivityHuman,Mouse,Rat
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ApplicationWB
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Recommended dilutionWB 1:500-1:2000
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Western blot analysis of extracts from Jurkat cells, treated with EGF (200ng/ml, 5mins), using AKT1 (Phospho-Thr308) antibody.
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