Phospho-CDC2 (Thr161) Antibody
Source: Rabbit pAb Catalog No. : CY6096
Phospho-CDC2 (Thr161) Antibody (CY6096)
UniProt:P06493
Application:WB,IHC
Reactivity:Human,Mouse,Rat
Source:Rabbit pAb
References（1）
http://www.abways.cn/showproduct.asp?cid=CY6096
数据表
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UniProt
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Mol Weight34KD
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Alternative NamesCDC28, CDC2A, CDK1, Cell division control protein 2 homolog, Cyclin-dependent kinase 1, EC 2.7.11.22, EC 2.7.11.23, MPF, kinase Cdc2, p34 protein kinase
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ImmunogenThe antiserum was produced against synthesized phosphopeptide derived from human CDC2 around the phosphorylation site of Threonine161
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityPolyclonal
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DescriptionSerine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation
Applications
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ReactivityHuman,Mouse,Rat
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ApplicationWB,IHC
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Recommended dilutionWB 1:500~1:1000 IHC 1:50~1:200
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Western blot analysis using CDC2 (Phospho-Thr161) Antibody: Line1: The extracts from COLO cells using preincubated with synthesized phosphopeptide; Line2: The extracts from COLO cells. Line3: The extracts from K562 cells. -
Immunohistochemical analysis of paraffin-embedded breast carcinoma, using CDC2(Phospho-Thr161) Antibody. Left: Untreated; Right: Treated with synthesized phosphopeptide.
引用文献（1条）
miR-6077 promotes cisplatin/pemetrexed resistance in lung adenocarcinoma via CDKN1A/cell cycle arrest and KEAP1/ferroptosis pathways-Molecular Therapy - Nucleic Acids (MOL THER-NUCL ACIDS)
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