Phospho-PKR (Thr446) Antibody
Source: Rabbit pAb Catalog No. : CY6441
Phospho-PKR (Thr446) Antibody (CY6441)
UniProt:P19525
Application:WB
Reactivity:Human
Source:Rabbit pAbhttp://www.abways.cn/showproduct.asp?cid=CY6441
数据表
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UniProt
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Mol Weight74kDa
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Alternative NamesEC 2.7.11.1 Interferon-inducible RNA-dependent protein kinase Eukaryotic translation initiation factor 2-alpha kinase 2 eIF-2A protein kinase 2 Protein kinase RNA-activated PKR p68 kinase P1/eIF-2A protein kinase
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ImmunogenA synthesized peptide derived from human PKR around the phosphorylation site of Threonine 446
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityPolyclonal
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DescriptionPKR a protein kinase of the PEK family. Upon binding double-stranded RNA, it becomes autophosphorylated and activated. Phosphorylates and inhibits the alpha subunit of eIF2 alpha, which leads to an inhibition of the initiation of protein synthesis.
Applications
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ReactivityHuman
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ApplicationWB
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Recommended dilutionWB 1:500-1:2000
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Western blot analysis of PKR phosphorylation expression in Starvation treated K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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