Phospho-Histone H2A.X (S139) Antibody
Source: Rabbit mAb Catalog No. : CY6572
Phospho-Histone H2A.X (S139) Antibody (CY6572)
UniProt:P16104
Application:WB,IHC,ICC/IF,IP
Reactivity:Human,Mouse,Rat
Source:Rabbit mAb
References（5）
http://www.abways.cn/showproduct.asp?cid=CY6572
数据表
-
UniProt
-
Mol Weight15kDa
-
Alternative NamesH2A.X; H2AFX; H2a/x; HIST5-2AX; Histone H2A.X;
-
ImmunogenA synthesized peptide derived from human Phospho-Histone H2A.X (S139)
-
StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
-
PurificationAffinity-chromatography
-
IsotypeRabbit IgG
-
ClonalityMonoclonal
-
DescriptionVariant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
Applications
-
ReactivityHuman,Mouse,Rat
-
ApplicationWB,IHC,ICC/IF,IP
-
Recommended dilutionWB 1:5000~1:10000 IHC 1:50~1:200 ICC 1:50~1:200 IP 1:30
-
Western blot analysis of HistoneH2A.X phosphorylation expression in Jurkat cell lysate treated with etoposide. -
Immunohistochemical analysis of paraffin-embedded mouse liver, using Phospho-Histone H2A.X (S139) Antibody. -
Immunofluorescent analysis of HeLa cells treated with H2O2, using Phospho-Histone H2A.X (S139) Antibody. -
SRSF1 Prevents DNA Damage and Promotes Tumorigenesis through Regulation of DBF4B Pre-mRNA Splicing. -Cell Reports -
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature. -
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature. -
All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
引用文献（5条）
SRSF1 Prevents DNA Damage and Promotes Tumorigenesis through Regulation of DBF4B Pre-mRNA Splicing.-Cell Reports
Administration of trastuzumab with heart irradiation induced acute cardiotoxicity in mice-American Journal of Cancer Research (Am J Cancer Res)
Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice-Communications Biology (COMMUN BIOL)
Asparaginyl endopeptidase (AEP) regulates myocardial apoptosis in response to radiation exposure via alterations in NRF2 activation-American Journal of Cancer Research (Am J Cancer Res)
AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/STAT3 axis-mediated positive feedback loop-Mechanisms of Ageing and Development (MECH AGEING DEV)
销售咨询
一键电话