ULK1 Antibody
Source: Rabbit mAb Catalog No. : CY6902
ULK1 Antibody (CY6902)
UniProt:O75385
Application:WB,IHC,ICC/IF
Reactivity:Human,Mouse,Rat
Source:Rabbit mAbhttp://www.abways.cn/showproduct.asp?cid=CY6902
数据表
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UniProt
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Mol Weight120kDa
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Alternative NamesSerine/threonine-protein kinase ULK1; Autophagy-related protein 1 homolog; ATG1; Unc-51-like kinase 1; ULK1;
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ImmunogenA synthesized peptide derived from human ULK1
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityMonoclonal
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DescriptionAct as a convergence point for multiple signals that control autophagy, and can bind to several autophagy-related (Atg) proteins, regulating phosphorylation states and protein trafficking. AMPK, activated during low nutrient conditions, directly phosphorylates ULK1 at multiple sites including Ser317, Ser555, and Ser777. Conversely, mTOR, which is a regulator of cell growth and an inhibitor of autophagy, phosphorylates ULK1 at Ser757 and disrupts the interaction between ULK1 and AMPK.
Applications
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ReactivityHuman,Mouse,Rat
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ApplicationWB,IHC,ICC/IF
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Recommended dilutionWB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200
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All lanes use the Antibody at 1:3K dilution for 1 hour at room temperature. -
Western blot analysis of ULK1 expression in (1) HEK293 cell lysate; (2) PC12 cell lysate. -
Immunohistochemical analysis of paraffin-embedded human heart, using ULK1 Antibody. -
Immunofluorescent analysis of 293 cells, using ULK1 Antibody . -
Immunofluorescent analysis using the Antibody at 1:100 dilution.
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