PRAS40 Antibody
Source: Rabbit mAb Catalog No. : CY6904
PRAS40 Antibody (CY6904)
UniProt:Q96B36
Application:WB,IHC,IP,FC
Reactivity:Human,Mouse
Source:Rabbit mAbhttp://www.abways.cn/showproduct.asp?cid=CY6904
数据表
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UniProt
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Mol Weight40kDa
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Alternative Names40 kDa proline rich AKT substrate; AKT1 S1; AKT1 substrate 1 (proline rich); AKT1S1; Lobe; PRAS40; Proline rich akt substrate;
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ImmunogenA synthesized peptide derived from human PRAS40
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityMonoclonal
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DescriptionPRAS40 interacts with Raptor in mTOR complex 1 (mTORC1) in insulin-deprived cells and inhibits the activation of the mTORC1 pathway mediated by the cell cycle protein Rheb. Phosphorylation of PRAS40 by Akt at Thr246 relieves PRAS40 inhibition of mTORC1. mTORC1 in turn phosphorylates PRAS40 at Ser183.
Applications
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ReactivityHuman,Mouse
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ApplicationWB,IHC,IP,FC
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Recommended dilutionWB 1:500~1:2000 IHC 1:50~1:200 IP 1:50 FC 1:50
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All lanes use the Antibody at 1:3K dilution for 1 hour at room temperature. -
Western blot analysis of PRAS40 expression in 293T cell lysate.
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