Phospho-MLKL (S358) Antibody
Source: Rabbit mAb Catalog No. : CY7146
Phospho-MLKL (S358) Antibody (CY7146)
UniProt:Q8NB16
Application:WB,IHC
Reactivity:Human
Source:Rabbit mAbhttp://www.abways.cn/showproduct.asp?cid=CY7146
数据表
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UniProt
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Mol Weight54kDa
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Alternative NameshMLKL; Mlkl;
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ImmunogenA synthesized peptide derived from human Phospho-MLKL (S358)
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityMonoclonal
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DescriptionPseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Applications
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ReactivityHuman
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ApplicationWB,IHC
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Recommended dilutionWB 1:500~1:2000 IHC 1:50~1:200
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All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature. -
Western blot analysis of Phospho-MLKL (S358) expression in (1) HT-29 cell lysate; (2) HT-29 cell lysate treated with TNF alpha+ Smac mimetic+ z-VAD.
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