Hamartin Antibody
Source: Rabbit mAb Catalog No. : CY8013
Hamartin Antibody (CY8013)
UniProt:Q92574
Application:WB,IHC,ICC/IF,FC
Reactivity:Human
Source:Rabbit mAbhttp://www.abways.cn/showproduct.asp?cid=CY8013
数据表
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UniProt
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Mol Weight150kDa
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Alternative NamesHamartin; kiaa0243; LAM; TSC; Tsc1; Tuberous sclerosis 1;
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ImmunogenA synthesized peptide derived from human Hamartin
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityMonoclonal
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DescriptionIn complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
Applications
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ReactivityHuman
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ApplicationWB,IHC,ICC/IF,FC
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Recommended dilutionWB 1:1000~1:5000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:200
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Western blot analysis of Hamartin expression in HeLa cell lysate.
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