Phospho-BAD (Ser112) Antibody
Source: Rabbit pAb Catalog No. : AY0903
Phospho-BAD (Ser112) Antibody (AY0903)
UniProt:Q92934
Application:WB,IHC
Reactivity:Human:S75,Mouse:S112,Rat:S113
Source:Rabbit pAbhttp://www.abways.cn/showproduct.asp?cid=AY0903
数据表
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UniProt
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Mol Weight23 kDa
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Alternative NamesBAD, BBC6, BCL2L8, Bcl- XL/Bcl-2 associated death promoter, Bcl-2 binding component 6, Bcl-2-like 8 protein, Bcl-xL/Bcl-2 associated death promoter, Bcl2-antagonist of cell death
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ImmunogenThe antiserum was produced against synthesized phosphopeptide derived from human BAD around the phosphorylation site of serine 75 (H-S-SP-Y-P).
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StorageRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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PurificationAffinity-chromatography
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IsotypeRabbit IgG
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ClonalityPolyclonal
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DescriptionPromotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Applications
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ReactivityHuman:S75,Mouse:S112,Rat:S113
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ApplicationWB,IHC
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Recommended dilutionWB: 1:500~1:3000 IHC: 1:50~1:100 ELISA: 1:5000
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Western blot analysis of extracts from 293 cells treated with forskolin, using BAD (phospho-Ser112) antibody. -
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BAD (phospho-Ser112) antibody.
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